2011-08-15, 08:43 AM
Because what you typed is: double stranded DNA. What the paper exactly says is: double stranded RNA.
And I'll explain what happens a little more. In the replication process of HIV and several other similar retroviruses, the (+)-RNA strand 1) is expressed directly to give some viral protein machinery, and 2) is used as a template for RNA-dependent DNA polymerase (a.k.a. reverse transcriptase). The RNA in this RNA-DNA duplex is degraded, and that (-)-DNA strand now serves as a template for DNA synthesis to give a double-stranded DNA. Therefore, theoretically, the closest thing to a double-stranded RNA in a HIV cell is either 1) siRNA or miRNA, or 2) the RNA-DNA duplex. None of these are exactly the same as double stranded RNA, and for damn good reasons this serves to doubt the effectiveness of DRACO on HIV-infected cells.
I don't say things for nothing. It is a glaringly obvious error in your hover spoiler, for anyone sufficiently well versed in science.
Oh I'll throw in one more query - excessive interferon-like response resulting in disruption in bodily function e.g. excessive inflammation. Not terribly different from the query on excessive apoptotic effects w.r.t. the body.
One last edit: HIV is unique because it attacks the very system that is supposed to guard us - our immune system. The same goes for cancer - one key hallmark of cancer cells is the loss of at least one tumour suppressor gene (product), notably p53 (yeah yeah). Those are supposed to protect us, so if what protects us now fails... then... obviously the rest will start to crumble.
Hadriel
And I'll explain what happens a little more. In the replication process of HIV and several other similar retroviruses, the (+)-RNA strand 1) is expressed directly to give some viral protein machinery, and 2) is used as a template for RNA-dependent DNA polymerase (a.k.a. reverse transcriptase). The RNA in this RNA-DNA duplex is degraded, and that (-)-DNA strand now serves as a template for DNA synthesis to give a double-stranded DNA. Therefore, theoretically, the closest thing to a double-stranded RNA in a HIV cell is either 1) siRNA or miRNA, or 2) the RNA-DNA duplex. None of these are exactly the same as double stranded RNA, and for damn good reasons this serves to doubt the effectiveness of DRACO on HIV-infected cells.
I don't say things for nothing. It is a glaringly obvious error in your hover spoiler, for anyone sufficiently well versed in science.
Oh I'll throw in one more query - excessive interferon-like response resulting in disruption in bodily function e.g. excessive inflammation. Not terribly different from the query on excessive apoptotic effects w.r.t. the body.
One last edit: HIV is unique because it attacks the very system that is supposed to guard us - our immune system. The same goes for cancer - one key hallmark of cancer cells is the loss of at least one tumour suppressor gene (product), notably p53 (yeah yeah). Those are supposed to protect us, so if what protects us now fails... then... obviously the rest will start to crumble.
Hadriel